HMGB1 triggers the release of cytokines-a collection of chemical signals-that generate inflammation in your body, according to research from back in 2014. This deadly cytokine storm occurs when normal inflammation goes crazy! Elevated HMGB1 levels are associated with many acute and chronic inflammatory disorders: Asthma and chronic obstructive pulmonary disease ( COPD). Atherosclerosis, lipid disturbances, coronary artery disease, heart attacks, strokes, and congestive heart failure. Auto immune disorders, including lupus, multiple sclerosis, rheumatoid arthritis, type 1 diabetes and others. Cancer, Diabetes, Inflammatory bowel ( Crohns Disease and ulcerative colotis) Neurodegenerative disorders, obesity, surgical procedures, trauma and Viral and other infections.
Calm the Cytokine Storm ! Your body ages more rapidly the more chronic inflammation you have. Many chronic diseases that cause premature death and disability are elevated by increase in levels of inflammation. By controlling HMGB1, the cytokine storm calms. Time tested non drug discoveries like how mung bean and green tea offer natural therapy. Studies show that mung bean seed coat extract and EGCG from green tea prevent death from acute inflammation caused by HMGB1 the literal cytokine switch!
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